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Duchenne Muscular Dystrophy

New Duchenne Muscular Dystrophy Findings from University of Oxford Described

Published in Gene Therapy Weekly, August 25th, 2011

2011 AUG 25 -- "Induced splice modulation of pre-mRNAs shows promise to correct aberrant disease transcripts and restore functional protein and thus has therapeutic potential. Duchenne muscular dystrophy (DMD) results from mutations that disrupt the DMD gene open reading frame causing an absence of dystrophin protein," scientists in Oxford, United Kingdom report.

"Antisense oligonucleotide (AO)-mediated exon skipping has been shown to restore functional dystrophin in mdx mice and DMD patients treated intramuscularly in two recent phase 1 clinical trials. Critical to the therapeutic success of AO-based treatment will be the ability to deliver AOs...

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