Amyotrophic Lateral Sclerosis

Human-cell-derived model of ALS provides a new way to study the majority of cases

Published in Gene Therapy Weekly, August 25th, 2011

2011 AUG 25 -- For decades, scientists have studied a laboratory mouse model that develops signs of the paralyzing disease amyotrophic lateral sclerosis (ALS) as they age. In a new study appearing in Nature Biotechnology, investigators at Nationwide Children's Hospital have developed a new model of ALS, one that mimics sporadic ALS, which represents about 90 percent of all cases.

ALS, commonly known as Lou Gehrig's disease, is characterized by the death of motor neurons, which are muscle-controlling nerve cells in the spinal cord. As these neurons die, the body's voluntary muscles weaken and waste away; death within five years of diagnosis is common. Only...

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Source: Gene Therapy Weekly (2011-08-25)

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