Gene Therapy
Findings from C. Yazici and Co-Researchers Advance Knowledge in Gene Therapy
Published in Gene Therapy Weekly, September 1st, 2011
2011 SEP 1 -- According to the authors of recent research published in the journal Molecular Therapy, "Structural allografts used for critical bone defects have limited osteogenic properties for biointegration. Although ex vivo tissue-engineered constructs expressing bone morphogenetic protein-2 (BMP2) have demonstrated efficacy in critical defect models, similar success has not been achieved with off-the-shelf acellular approaches, including allografts coated with freeze-dried single-stranded adeno-associated virus (ssAAV-BMP2)."
"To see whether the self-complementary AAV serotype 2.5 vector (scAAV2.5-BMP2) could overcome this, we performed...
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Source: Gene Therapy Weekly (2011-09-01)
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