Cancer Gene Therapy

University of Arizona Reports Research in Cancer Gene Therapy

Published in Gene Therapy Weekly, September 22nd, 2011

2011 SEP 22 -- According to the authors of a study from Tucson, Arizona, "The c-fms proto-oncogene encoded CSF-1 receptor and its ligand represent a feedback loop, which in a paracrine manner, is well known to promote spread of breast cancers. The role of the autocrine feedback loop in promotion of breast tumor behavior, in particular in vitro, is less well understood."

"The physiologic stimulation of c-fms expression by glucocorticoids (GCs) in vitro and in vivo magnifies the tumor promoting effect seen in these cells from activated c-fms signaling by CSF-1. Targeted molecular therapy against c-fms could therefore abrogate both complementary feedback...

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Source: Gene Therapy Weekly (2011-09-22)

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