Antisense Technology

Research from University of Naples in the Area of Antisense Technology Published

Published in Gene Therapy Weekly, September 22nd, 2011

2011 SEP 22 -- According to the authors of a study from Naples, Italy, "Nucleic acids designed to modulate the expression of target proteins remain a promising therapeutic strategy in several diseases, including cancer. However, clinical success is limited by the lack of efficient intracellular delivery."

"In this study we evaluated whether electroporation could increase the delivery of antisense oligodeoxynucleotides against bcl-2 (G3139) as well as the efficacy of combination chemotherapy in human melanoma xenografts. Melanoma-bearing nude mice were treated i.v. with G3139 and/or cisplatin (DDP) followed by the application of trains of electric pulses to...

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Source: Gene Therapy Weekly (2011-09-22)

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