Studies from University of Leeds Update Current Data on Gene Therapy

2011 SEP 22 -- Current study results from the report, "The roles of cell surface attachment molecules and coagulation Factor X in adenovirus 5-mediated gene transfer in pancreatic cancer cells," have been published. "Transduction of 11 pancreatic cancer cell lines with a replication-deficient adenovirus 5 expressing enhanced green fluorescent protein (Ad5EGFP) was analyzed and variable EGFP levels were observed, ranging from <1% to ~40% of cells transduced, depending on the cell line. Efficient Ad5EGFP transduction was associated mainly with higher levels of cell surface Coxsackie and adenovirus receptor (CAR) but not with expression of a(v)ß(3) and a(v)ß(5)...

Want to see the full article?

• Purchase this article for only $3.00