Small Interference RNAs (siRNAs)
New Small Interference RNAs (siRNAs) Research Reported from POSTECH
Published in Gene Therapy Weekly, September 22nd, 2011
2011 SEP 22 -- "Target-specific intracellular delivery of small interfering RNA (ANA) is regarded as. one of the most Important technologies for the development of ANA therapeutics. In this work, a cysteamine modified gold nanoparticles (AuCM)/siRNA/polyethyleneimine (PEI)/hyaluronic acid (HA) complex was successfully developed using a layer-by-layer method for target-specific intracellular delivery of siRNA by HA receptor mediated endocytosis," scientists in Pohang, South Korea report.
"Atomic force microscopic and zeta potential analyses confirmed the formation of a AuCM/siRNA/PEI/HA complex having a particle size of ca. 37.3 nm and a negative surface...
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Source: Gene Therapy Weekly (2011-09-22)
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