Gene Therapy

Studies from University of Munich Add New Findings in the Area of Gene Therapy

Published in Gene Therapy Weekly, September 22nd, 2011

2011 SEP 22 -- "Aerosol gene delivery holds great therapeutical potential for many inherited and acquired pulmonary diseases. The physical instability of aqueous suspensions of non-viral vector complexes is a major limitation for their successful application," scientists in Munich, Germany report.

"In this study, we investigated dry powder aerosols as novel gene vector formulations for gene transfer in vitro and murine lungs in vivo. Lyophilization was used to produce dry powder cakes followed by powderization to produce dry powder aerosols. Different sugars, namely lactose, sucrose and trehalose, were tested as lyoprotectants for gene delivery complexes...

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Source: Gene Therapy Weekly (2011-09-22)

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