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Gene Therapy

Researchers from Fred Hutchinson Cancer Research Center Publish New Studies and Findings in the Area of Gene Therapy

Published in Gene Therapy Weekly, September 29th, 2011

2011 SEP 29 -- "Gammaretroviral vectors are an efficient means to effect gene therapy. However, genotoxicity from insertion at nonrandom sites can confer a competitive advantage to transduced cells, resulting in clonal proliferation or neoplasia," researchers in Seattle, Washington report.

"Six pig-tailed macaques (Macaca nemestrina) underwent total body irradiation and reconstitution with autologous stem cells genetically modified by a gammaretroviral vector overexpressing HOXB4. Two animals were euthanized owing to irradiation-or transplantation-associated toxicity, whereas the other 4 had successful reconstitution. Of the 4 macaques with successful...

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