Chronic Hepatitis C Virus

Researchers at University Hospital Center Release New Data on Chronic Hepatitis C Virus

Published in Gene Therapy Weekly, September 29th, 2011

2011 SEP 29 -- "Therapy for chronic hepatitis C (CHC) has limited efficacy, adverse effects, and high costs. Cohort and vaccine-based preclinical studies have indicated the importance of T-cell-based immunity in controlling viral infection," investigators in Grenoble, France report.

"TG4040 is a recombinant poxvirus vaccine that expresses the hepatitis C virus (HCV) proteins NS3, NS4, and NS5B. We performed a phase I clinical trial to assess the safety, immunogenicity, and early antiviral efficacy of TG4040 in patients with CHC. In an open-label, dose-escalating study, patients with mild CHC (genotype 1) were assigned to 3 groups of 3 patients each; they...

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Source: Gene Therapy Weekly (2011-09-29)

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