Gene Therapy
Recent Studies from University of Fudan Add New Data to Gene Therapy
Published in Gene Therapy Weekly, October 27th, 2011
2011 OCT 27 -- "Phi C31 integrase is a member of the large serine subfamily and is required for the recombination of the phage genome into the host chromosome, either to establish or exit from the lysogenic state. This enzyme can also mediate site-specific integration in mammalian cells in a cofactor-independent manner and has been considered as a potentially powerful tool for gene therapy," investigators in Shanghai, People's Republic of China report.
"It has previously been reported that DAXX interacts with Phi C31 integrase and markedly inhibits its integration efficiency, and the 451RFGK454 tetramer of Phi C31 integrase has been identified as the...
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Source: Gene Therapy Weekly (2011-10-27)
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