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Small Interference RNAs (siRNAs)

Researchers from KRIBB Report Details of New Studies and Findings in the Area of Small Interference RNAs (siRNAs)

Published in Gene Therapy Weekly, October 27th, 2011

2011 OCT 27 -- According to the authors of recent research published in the International Journal of Cancer, "HFE is a protein that impacts cellular iron uptake. HFE gene variants are identified as risk factors or modifiers for multiple diseases."

"Using HFE stably transfected human neuroblastoma cells, we found that cells carrying the C282Y HFE variant do not differentiate when exposed to retinoic acid. Therefore, we hypothesized HFE variants would impact response to therapeutic agents. Both the human neuroblastoma and glioma cells that express the C282Y HFE variant are resistant to Temodar, geldanamycin and gamma-radiation. A gene array analysis...

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