Multidrug Resistance

University of Shandong Reports Research in Multidrug Resistance

Published in Gene Therapy Weekly, October 27th, 2011

2011 OCT 27 -- "Specific inhibition of P-glycoprotein (Pgp) expression, which is encoded by multidrug resistance gene-1 (MDR1), is considered a well-respected strategy to overcome multidrug resistance (MDR). Deoxyribozymes (DRz) are catalytic nucleic acids that could cleave a target RNA in sequence-specific manner," researchers in Jinan, People's Republic of China report.

"However, it is difficult to select an effective target site for DRz in living cells. In this study, target sites of DRz were screened according to MDR1 mRNA secondary structure by RNA structure analysis software. Twelve target sites on the surface of MDR1 mRNA were selected. Accordingly,...

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Source: Gene Therapy Weekly (2011-10-27)

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