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Nanoparticles

Reports from University of Santiago Advance Knowledge in Nanoparticles

Published in Gene Therapy Weekly, November 3rd, 2011

2011 NOV 3 -- "Decreased production of the mucin MUC5AC in the eye is related to several pathological conditions, including dry eye syndrome. A specific strategy for increasing the ocular levels of MUC5AC is not yet available," investigators in Santiago de Compostela, Spain report.

"Using a plasmid specially designed to encode human MUC5AC, we evaluated the ability of hybrid cationized gelatin nanoparticles (NPs) containing polyanions (chondroitin sulfate or dextran sulfate) to transfect ocular epithelial cells. NPs were developed using the ionic gelation technique and characterized by a small size (<200 nm), positive zeta potential (+20/+30 mV), and...

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