Developmental Biology

Researchers at Texas A&M University Target Developmental Biology

Published in Gene Therapy Weekly, November 3rd, 2011

2011 NOV 3 -- "Atoh1 is required for differentiation of sensory hair cells in the vertebrate inner ear. Moreover, misexpression of Atoh1 is sufficient to establish ectopic sensory epithelia, making Atoh1 a good candidate for gene therapy to restore hearing," investigators in College Station, Texas report.

"However, competence to form sensory epithelia appears to be limited to discrete regions of the inner ear. To better understand the developmental factors influencing sensory-competence, we examined the effects of misexpressing atoh1a in zebrafish embryos under various developmental conditions. Activation of a heat shock-inducible transgene, hs:atoh1a,...

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Source: Gene Therapy Weekly (2011-11-03)

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