Gene Therapy

Studies in the Area of Gene Therapy Reported from University of London

Published in Gene Therapy Weekly, November 10th, 2011

2011 NOV 10 -- "Several diseases and injuries of the central nervous system could potentially be treated by delivery of an enzyme, which might most effectively be achieved by gene therapy. In particular, the bacterial enzyme chondroitinase ABC is beneficial in animal models of spinal cord injury," investigators in Egham, United Kingdom report.

"We have adapted the chondroitinase gene so that it can direct secretion of active chondroitinase from mammalian cells, and inserted it into lentiviral vectors. When injected into adult rat brain, these vectors lead to extensive secretion of chondroitinase, both locally and from long-distance axon projections, with...

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Source: Gene Therapy Weekly (2011-11-10)

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