Biological Pigments

Findings from C.H. Peng and Co-Authors Provide New Insights into Biological Pigments

Published in Gene Therapy Weekly, November 24th, 2011

2011 NOV 24 -- According to the authors of recent research from Taipei, Taiwan, "Cationic polyurethane, a biodegradable non-viral vector, protects DNA from nuclease degradation and helps to deliver genes efficiently. Oct4, a POU-domain transcription factor, is highly expressed in maintaining pluripotency and cellular reprogramming process in stem cells."

"SirT1, a NAD-dependent histone deacetylase, is an essential mediator of cellular longevity. Herein we demonstrated that both Oct4 and SirT1 (Oct4/SirT1) expression was decreased in an age-dependent manner in retina with aged-related macular degeneration and retinal pigment epithelium cells (RPEs). To...

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Source: Gene Therapy Weekly (2011-11-24)

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