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Adenocarcinomas

Reports from Chaim Sheba Medical Center Describe Recent Advances in Adenocarcinomas

Published in Gene Therapy Weekly, November 24th, 2011

2011 NOV 24 -- According to the authors of a study from Ramat Gan, Israel, "Curative surgery is possible in barely 10% of patients with colorectal liver metastases and combined treatment modalities scarcely improve survival in this group of patients. Hence, investigations of new therapeutic modalities are crucial."

"Overexpression of the H19 gene in liver metastases points to H19 as a target for cancer gene therapy. Here we have evaluated the possibility of regional intra-arterial treatment of liver metastases with the DTA-H19 plasmid. Intra-arterial treatment of a total dose of 2.5 mg (repeated injections of 500 mu g DTA-H19 plasmid each dose after the...

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