Antisense Technology

Researchers from Korea Advanced Institute of Science and Technology (KAIST) Describe Findings in Antisense Technology

Published in Gene Therapy Weekly, November 24th, 2011

2011 NOV 24 -- According to the authors of a study from Taejon, South Korea, "In order for peptide nucleic acids (PNAs) to be effective as therapeutic agents, methods for cellular delivery must be developed. Here we demonstrate spontaneous nuclear localization and antisense effects of peptide nucleic acids (PNAs) delivered to hepatic cells through asialoglycoprotein receptor-mediated endocytosis."

"Asialofetuin conjugates with DNA oligonucleotides (AF/DNA) complementary to the PNA of interest were designed as cell-specific delivery vectors. PNAs hybridized to the asialofetuin-oligonucleotide conjugates were internalized into murine primary hepatocytes and...

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Source: Gene Therapy Weekly (2011-11-24)

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