Sepsis
Investigators at Vascular Biology Center Target Sepsis
Published in Gene Therapy Weekly, November 24th, 2011
2011 NOV 24 -- New research, "The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): beneficial or detrimental to endothelial barrier," is the subject of a report. "Sepsis-induced vascular leakage is a major underlying cause of the respiratory dysfunction seen in severe sepsis. Here, we studied the role of MLC phosphorylation in LPS-induced endothelial hyperpermeability and assessed how the changes in phospho-MLC distribution affect LPS-induced barrier dysfunction," investigators in Augusta, Georgia report.
"We demonstrated that the changes in human lung microvascular endothelial permeability are...
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Source: Gene Therapy Weekly (2011-11-24)
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