Small Interference RNAs (siRNAs)

New Small Interference RNAs (siRNAs) Study Results from University of Tel Aviv Described

Published in Gene Therapy Weekly, November 24th, 2011

2011 NOV 24 -- "Autoproteolytic cleavage of the inactive acid ceramidase (AC) precursor into the active heterodimer exposes a free cysteine residue, leading us to study whether AC could be regulated by one or more members of the cystatin family. Co-expression of the full-length AC and cystatin SA (cysSA) cDNAs led to significant reduction of AC activity in the transfected cells," investigators in Tel Aviv, Israel report.

"Expression of cysSA also inhibited endogenous AC activity in cells and increased ceramide. Conversely, cysSA siRNA expression led to elevated AC activity and reduction in ceramide. The effects of cysSA siRNA expression could be reversed by...

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Source: Gene Therapy Weekly (2011-11-24)

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