Mononuclear Phagocyte System

Research from Polish Academy of Sciences Yields New Findings on Mononuclear Phagocyte System

Published in Gene Therapy Weekly, December 1st, 2011

2011 DEC 1 -- "Antigen-loaded dendritic cells (DCs) are a promising tool for inducing a tumor-specific immune response. It seems probable that co-administration of those cells together with cytokine-transduced DCs can further increase effectiveness of the antitumor vaccine," scientists writing in the journal Immunobiology report.

"The local production of IL-2 by genetically modified DCs may result in alteration of the unfavorable tumor environment causing immune response dysfunction. In the presented study murine DCs of an established JAWS II cell line were transduced with a retroviral vector carrying murine IL-2 gene (JAWS II/IL-2). JAWS II/IL-2...

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Source: Gene Therapy Weekly (2011-12-01)

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