Gene Therapy

New Gene Therapy Research from Ohio State University Discussed

Published in Gene Therapy Weekly, December 1st, 2011

2011 DEC 1 -- According to the authors of recent research published in the Journal of Virology, "Recombinant adeno-associated virus (rAAV) vectors establish persistent transgene expression in the skeletal muscle of mice. How dendritic cells acquire encoded antigens for CD8(+) T-cell priming is unknown."

"Here we document CD8(+) T-cell priming after lethal irradiation and bone marrow reconstitution of mice treated with an AAV vector several weeks earlier. Temporal separation of vector delivery and successful class I antigen presentation indicated that T-cell priming does not necessarily require antigen synthesis in AAV-transduced dendritic cells,"...

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Source: Gene Therapy Weekly (2011-12-01)

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