Gene Therapy

New Gene Therapy Study Findings Have Been Reported from University of Washington

Published in Gene Therapy Weekly, December 8th, 2011

2011 DEC 8 -- "Adenoviral (AdV) gene vectors offer efficient nucleic acid transfer into both dividing and non-dividing cells. However issues such as vector immunogenicity, toxicity and restricted transduction to receptor-expressing cells have prevented broad clinical translation of these constructs," researchers in Seattle, Washington report.

"To address this issue, engineered AdV have been prepared by both genetic and chemical manipulation. In this work, a polymer-coated Ad5 formulation is optimized by evaluating a series of N-(2-hydroxypropyl) methacrylamide (HPMA)-co-oligolysine copolymers synthesized by living polymerization techniques. This synthesis...

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Source: Gene Therapy Weekly (2011-12-08)

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