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Small Interference RNAs (siRNAs)

Studies from University of Tel Aviv Have Provided New Information about Small Interference RNAs (siRNAs)

Published in Gene Therapy Weekly, December 8th, 2011

2011 DEC 8 -- According to the authors of recent research from Tel Aviv, Israel, "New targets for RNAi-based cancer therapy are constantly emerging from the increasing knowledge on the key molecular pathways that are paramount for carcinogenesis."

"Nevertheless, in vivo delivery of siRNA remains a crucial challenge for its therapeutic success. siRNAs on their own are not taken-up by most mammalian cells in a way that preserves their activity," wrote W. Fischer and colleagues, University of Tel Aviv.

The researchers concluded: "Moreover, when applied in vivo, siRNA-based approaches are all limited by poor penetration into the target...

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