Research in the Area of Gene Therapy Reported from X.Y. Li and Colleagues

2011 DEC 15 -- "Bax inhibitor-1 (Bi-1), an anti-apoptotic protein that belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway to suppress Bax-induced apoptosis. in several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased; however, up-regulated expression of this protein has been linked to increased cell proliferations. In this study, we down-regulated the gene expression of Bit in nasopharyngeal carcinoma cells by using a lentivirus transfection system packed with short hairpin RNA targeting Big and used an in vivo model to assess its efficacy as a target in human gene therapy," investigators in...

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