Gene Therapy

Data on Gene Therapy Discussed by Researchers at Kyungpook National University

Published in Gene Therapy Weekly, December 15th, 2011

2011 DEC 15 -- According to the authors of a study from Taegu, South Korea, "Hepatocellular carcinoma is a common malignancy. The carcinoma cells express glypican-3 (GPC-3) on the cell membrane."

"GPC-3 is also expressed in melanoma cells. Therefore, GPC-3 might be a potential target for tumor imaging or therapy. Here, proteomic mass spectrometry was used to identify peptides that target GPC-3-expressing tumors. A mammalian expression vector expressing a FLAG-GPC-3 fusion protein was cloned for immunoprecipitation. With the use of liposomes, the vector was transfected into HepG2 (HepG2/FLAG-GPC-3) and HEK 293 cells, and the transfected cell lines were...

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Source: Gene Therapy Weekly (2011-12-15)

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