Small Interference RNAs (siRNAs)

Hanyang University Reports Research in Small Interference RNAs (siRNAs)

Published in Gene Therapy Weekly, December 15th, 2011

2011 DEC 15 -- According to the authors of recent research from Kyonggi Do, South Korea, "Combined treatment of anticancer drugs and small interfering RNAs (siRNAs) have emerged as a new modality of anticancer therapy. Here, we describe a co-delivery system of anticancer drugs and siRNA in which anticancer drug-derived lipids form cationic nanoparticles for siRNA complexation."

"The anticancer drug mitoxantrone (MTO) was conjugated to palmitoleic acid, generating two types of palmitoleyl MTO (Pal-MTO) lipids: monopalmitoleyl MTO (mono-Pal-MTO) and dipalmitoleyl MTO (di-Pal-MTO). Among various lipid compositions of MTO, nanoparticles containing mono-Pal-MTO...

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Source: Gene Therapy Weekly (2011-12-15)

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