Cytoskeleton

Research from Polish Academy of Sciences Provides New Data about Cytoskeleton

Published in Gene Therapy Weekly, December 22nd, 2011

2011 DEC 22 -- "Purpose To investigate the mechanistic basis of the antitumor effect of the compound ITB-301. Methods Chemical modifications of genistein have been introduced to improve its solubility and efficacy," scientists in Warsaw, Poland report.

"The antitumor effects were tested in ovarian cancer cells using proliferation assays, cell cycle analysis, immunofluorescence, and microscopy. Results In this work, we show that a unique glycoside of genistein, ITB-301, inhibits the proliferation of SKOv3 ovarian cancer cells. We found that the 50% growth inhibitory concentration of ITB-301 in SKOv3 cells was 0.5 mu M. Similar results were obtained in breast...

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Source: Gene Therapy Weekly (2011-12-22)

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