Adenovirus
Data on Adenovirus Described by D. Abate-Daga et al
Published in Gene Therapy Weekly, December 22nd, 2011
2011 DEC 22 -- Research findings, "Oncolytic adenoviruses armed with thymidine kinase can be traced by PET imaging and show potent antitumoural effects by ganciclovir dosing," are discussed in a new report. According to the authors of a study from Barcelona, Spain, "Replication-competent adenoviruses armed with thymidine kinase (TK) combine the concepts of virotherapy and suicide gene therapy. Moreover TK-activity can be detected by noninvasive positron emission-computed tomography (PET) imaging, what could potentially facilitate virus monitoring in vivo."
"Here, we report the generation of a novel oncolytic adenovirus that incorporates the Tat8-TK gene...
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Source: Gene Therapy Weekly (2011-12-22)
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