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Antisense Technology

Research from Zhejiang University Yields New Findings on Antisense Technology

Published in Gene Therapy Weekly, January 12th, 2012

2012 JAN 12 -- "Previous studies have demonstrated that Homer 1b/c, a postsynaptic molecular scaffolding protein that binds and clusters metabotropic glutamate receptors at neuronal synapses, has an important role in the metabotropic glutamate receptor signaling process. In the current study, we investigated the possible involvement of Homer 1b/c in secondary hyperalgesia induced by complete Freund's adjuvant (CFA)," scientists writing in the journal Anesthesia and Analgesia report.

"Chronic inflammation was induced by injecting CFA into the left hind ankle of Wistar rats. Homer 1b/c antisense or missense oligonucleotides were intrathecally...

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