Gene Therapy
Researchers' Work from Technical University Focuses on Gene Therapy
Published in Gene Therapy Weekly, January 12th, 2012
2012 JAN 12 -- According to the authors of recent research published in the journal Human Gene Therapy, "We reported the therapeutic efficacy of I-131 in hepatocellular carcinoma (HCC) cells stably expressing the sodium iodide symporter (NIS) under the control of the tumor-specific alpha-fetoprotein (AFP) promoter. In the current study we investigated the efficacy of adenovirus-mediated in vivo NIS gene transfer followed by I-131 and Re-188 administration for the treatment of HCC xenografts."
"We used a replication-deficient adenovirus carrying the human NIS gene linked to the mouse AFP promoter (Ad5-AFP-NIS) for in vitro and in vivo NIS gene...
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Source: Gene Therapy Weekly (2012-01-12)
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