Gene Therapy

Studies from J. Rousseau and Colleagues Yield New Information about Gene Therapy

Published in Gene Therapy Weekly, January 19th, 2012

2012 JAN 19 -- According to the authors of recent research published in the Journal of Gene Medicine, "Background Various endonucleases can be engineered to induce double-strand breaks (DSBs) in chosen DNA sequences. These DSBs are spontaneously repaired by nonhomologous-end-joining, resulting in micro-insertions or micro-deletions (INDELs)."

"We detected, characterized and quantified the frequency of INDELs produced by one meganuclease (MGN) targeting the RAG1 gene, six MGNs targeting three introns of the human dystrophin gene and one pair of zinc finger nucleases (ZFNs) targeting exon 50 of the human dystrophin gene. The experiments were performed...

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Source: Gene Therapy Weekly (2012-01-19)

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