Guanidines
Reports on Guanidines Findings from McGill University Provide New Insights
Published in Gene Therapy Weekly, January 19th, 2012
2012 JAN 19 -- New research, "Relevance of the OCT1 transporter to the antineoplastic effect of biguanides," is the subject of a report. According to the authors of recent research from Montreal, Canada, "Epidemiologic and laboratory data suggesting that metformin has antineoplastic activity have led to ongoing clinical trials. However, pharmacokinetic issues that may influence metformin activity have not been studied in detail."
"The organic cation transporter 1 (OCT1) is known to play an important role in cellular uptake of metformin in the liver. We show that siRNA knockdown of OCT1 reduced sensitivity of epithelial ovarian cancer cells to metformin, but...
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Source: Gene Therapy Weekly (2012-01-19)
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