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HIV/AIDS

New HIV/AIDS Findings from University of Witwatersrand Published

Published in Gene Therapy Weekly, January 19th, 2012

2012 JAN 19 -- According to the authors of a study from Wits, South Africa, "Employing engineered DNA templates to express antiviral microRNA (miRNA) sequences has considerable therapeutic potential. The durable silencing that may be achieved with these RNAi activators is valuable to counter chronic viral infections, such as those caused by HIV-1, hepatitis B, hepatitis C and dengue viruses."

"Early use of expressed antiviral miRNAs entailed generation of cassettes containing Pol III promoters (e.g. U6 and H1) that transcribe virus-targeting short hairpin RNA mimics of precursor miRNAs. Virus escape from single gene silencing elements prompted later...

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