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Gene Therapy

Research Reports from R.Y. Tang and Co-Authors Provide New Insights into Gene Therapy

Published in Gene Therapy Weekly, February 2nd, 2012

2012 FEB 2 -- According to the authors of recent research published in the Journal of Immunotherapy, "Identification of adenoviral isolates of nonhuman origin has fostered development of vectors with potential to overcome preexisting immunity in the human population that may affect clinical applications. Ovine adenoviral isolate, OAdV287 (OAdV7), the prototype of the genus Atadenovirus, has been previously characterized as a gene delivery vector although the receptor(s) used for infection remain to be identified."

"Here, we report the first use of recombinant OAdV7 as a vaccine for inducing an antitumor immune response in a mouse model. Treatment of...

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