Endocytosis

Investigators from Cardiovascular Research Center Have Published New Data on Endocytosis

Published in Gene Therapy Weekly, February 16th, 2012

2012 FEB 16 -- According to the authors of recent research from New York City, New York, "Adeno-associated viruses (AAVs) are nonpathogenic, nonenveloped, single-stranded DNA viruses in development as gene therapy vectors. AAV internalization was postulated to proceed via a dynamin-dependent endocytic mechanism."

"Revisiting this, we find that infectious endocytosis of the prototypical AAV, AAV2, is independent of clathrin, caveolin, and dynamin. AAV2 infection is sensitive to EIPA, a fluid-phase uptake inhibitor, but is unaffected by Rac1 mutants or other macropinocytosis inhibitors. In contrast, AAV2 infection requires actin cytoskeleton remodeling and...

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Source: Gene Therapy Weekly (2012-02-16)

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