Apoptosis

Investigators from Tohoku University Release New Data on Apoptosis

Published in Gene Therapy Weekly, February 16th, 2012

2012 FEB 16 -- According to the authors of a study from Miyagi, Japan, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5)-mediated cell death plays an important role in the elimination of tumor cells and transformed cells. Recently, recombinant TRAIL and agonistic anti-DR5 monoclonal antibodies have been developed and applied to cancer therapy."

"However, depending on the type of cancer, the sensitivity to TRAIL has been reportedly different, and some tumor cells are resistant to TRAIL-mediated apoptosis. Using confocal microscopy, we found that large amounts of DR5 were localized in the nucleus in HeLa and HepG2 cells....

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Source: Gene Therapy Weekly (2012-02-16)

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