Gene Therapy
University of Washington Details Research in Gene Therapy
Published in Gene Therapy Weekly, February 23rd, 2012
2012 FEB 23 -- "Two major limitations to achieve efficient homing endonuclease-stimulated gene correction using retroviral vectors are low frequency of gene targeting and random integration of the targeting vectors. To overcome these issues, we developed a reporter system for quick and facile testing of novel strategies to promote the selection of cells that undergo targeted gene repair and to minimize the persistence of random integrations and non-homologous end-joining events," scientists writing in the journal Nucleic Acids Research report.
"In this system, the gene target has an I-SceI site upstream of an EGFP reporter; and the repair template...
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Source: Gene Therapy Weekly (2012-02-23)
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