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Vascular Endothelial Growth Factor

Reports from National Cancer Institute Describe Recent Advances in Vascular Endothelial Growth Factor

Published in Gene Therapy Weekly, March 8th, 2012

2012 MAR 8 -- New investigation results, "NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1a," are detailed in a study published in Molecular and Cellular Neuroscience. "Communication between the vasculature and nervous system is important during embryogenesis but the molecular mechanisms mediating this are ill-defined. We evaluated the molecular mechanisms by which Nerve Growth Factor (NGF) and Brain-derived neurotrophic factor (BDNF) regulate VEGF production," researchers in Bethesda, Maryland report.

"NGF activation of TrkA causes a marked increase in VEGF secretion by neuronal...

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