Small Interference RNAs (siRNAs)
Research from University of California Has Provided New Data on Small Interference RNAs (siRNAs)
Published in Gene Therapy Weekly, March 8th, 2012
2012 MAR 8 -- Investigators discuss in "Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles" new findings in Small Interference RNAs (siRNAs). According to the authors of a study from Irvine, California, "Despite viral vectors' predominant use in clinical trials, due to higher gene delivery efficiency than nonviral counterparts, intrinsic immunogenicity and limited tunability for multi-modal effects are major concerns for their usage in gene therapy. An adeno-associated viral (AAV) particle was shielded with acid-degradable, siRNA-encapsulating polyketal (PK) shell, resulting in core-shell viral/nonviral chimeric...
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Source: Gene Therapy Weekly (2012-03-08)
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