Gene Therapy
Findings from Kyungpook National University Broaden Understanding of Gene Therapy
Published in Gene Therapy Weekly, March 15th, 2012
2012 MAR 15 -- "This study was designed to determine the antiproliferative effects of combination gene therapy using sodium iodide symporter (NIS)-based radioiodine and lentivirus-mediated short hairpin RNA (shRNA) against hexokinase 11 (HKII) on vascular smooth muscle cells (VSMCs). A7r5 rat VSMCs were stably tmnsfected with a dual-expression vector of NIS and Flue (A7r5-NL cells)," scientists writing in the journal Nuclear Medicine and Biology report.
"Functional assessment was performed by radioiodine uptake assay, luciferase assay and confocal microscopy. After exposure to lentivirus-HKII-shRNA, the F-18-FDG uptake test and HK activity assay were...
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Source: Gene Therapy Weekly (2012-03-15)
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