Pattern Recognition Receptors
Study Results from University of Southern Denmark Broaden Understanding of Pattern Recognition Receptors
Published in Gene Therapy Weekly, March 15th, 2012
2012 MAR 15 -- Investigators publish new data in the report "Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response." According to the authors of a study from Odense, Denmark, "Within the central nervous system, astrocytes and microglia are the primary responders to endogenous ligands released upon injury and stress, as well as to infectious pathogens. Toll-like receptors (TLRs) are implicated in recognition of both types of stimulus."
"Whether astrocytes respond as strongly as microglia to TLR agonists remains contentious. In this study, we have rigorously purified astrocytes to determine their capacity...
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Source: Gene Therapy Weekly (2012-03-15)
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