Small Interference RNAs (siRNAs)
Studies from University of North Carolina Add New Findings in the Area of Small Interference RNAs (siRNAs)
Published in Gene Therapy Weekly, March 22nd, 2012
2012 MAR 22 -- Research findings, "Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA," are discussed in a new report. According to the authors of a study from Chapel Hill, North Carolina, "We have designed, synthesized, and tested conjugates of chemically modified luciferase siRNA (Luc-siRNA) with bi-, tri-, and tetravalent cyclic(arginine-glycine-aspartic) (cRGD) peptides that selectively bind to the avß3 integrin. The cellular uptake, subcellular distribution, and pharmacological effects of the cRGD-conjugated Luc-siRNAs compared to those of unconjugated controls were examined using a luciferase reporter cassette stably transfected into...
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Source: Gene Therapy Weekly (2012-03-22)
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