Cell Biology
Investigators at University of Bristol Discuss Research in Cell Biology
Published in Gene Therapy Weekly, April 26th, 2012
2012 APR 26 -- According to the authors of a study from Bristol, United Kingdom, "We have explored the possible role of dual specificity phosphatases (DUSPs) on acute EGF-mediated ERK signalling using high content imaging and a delayed MEK inhibition protocol to distinguish direct and indirect effects of the phosphatases on ERK activity. Using siRNAs, we were unable to find evidence that any of the MAPK phosphatases (MKPs) expressed in HeLa cells acts directly to dephosphorylate ppERK1/2 (dual phosphorylated ERKs 1 and/or 2) in the acute time-frame tested (0-14 min)."
"Nevertheless, siRNAs against two p38/JNK MKPs (DUSPs 10 and 16) inhibited acute...
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Source: Gene Therapy Weekly (2012-04-26)
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