Hormones

New Hormones Research Has Been Reported by Investigators at Veterans Affairs Medical Center

Published in Gene Therapy Weekly, April 26th, 2012

2012 APR 26 -- In this recently published study, investigators in Birmingham, Alabama conducted a study "Toll-like receptor 9 (TLR9) is a cellular DNA-receptor, which is widely expressed in cancer. Synthetic TLR9-ligands induce cancer cell invasion in vitro, but the role of TLR9 in cancer pathophysiology remains unclear."

"Increased TLR9 expression has been, however, detected in estrogen receptor negative (ER-) breast cancers. In this study, we investigated the effects of ER alpha expression and sex steroid hormones on TLR9 expression in human ER+ (MCF-7, T47-D) and ER- (MDA-MB-231) breast cancer cell lines in vitro. We also studied TLR9 mRNA expression in...

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Source: Gene Therapy Weekly (2012-04-26)

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