Small Interference RNAs (siRNAs)

Research from J. Liu and Co-Authors Reveals New Findings on Small Interference RNAs (siRNAs)

Published in Gene Therapy Weekly, April 26th, 2012

2012 APR 26 -- A new study, "Efficient systemic delivery of siRNA to the mouse liver by pegylated lipopolymer," is now available. "Short interfering RNA (siRNA) drugs have entered clinical trials in various disease areas. However, systemic use of siRNA drugs faces a challenge of tissue in-specificity and membrane impenetrability," investigators in Oceanside, California report.

"In this study, we hypothesized that the combined of lipidic molecules with a pegylated cationic polymer through random polymerization of Micheal reaction could enhance the hepatocyte's preferential uptake and improve membrane penetrability. We reported the efficacy of in vitro...

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Source: Gene Therapy Weekly (2012-04-26)

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