Gene Therapy
Findings from A.F. Rodrigues and Co-Authors Broaden Understanding of Gene Therapy
Published in Gene Therapy Weekly, May 10th, 2012
2012 MAY 10 -- "The manufacture of enveloped virus, particularly retroviral (RV) and lentiviral (LV) vectors, faces the challenge of low titers that are aggravated under serum deprivation culture conditions. Also, the scarce knowledge on the biochemical pathways related with virus production is still limiting the design of rational strategies for improved production yields," scientists writing in the journal Biotechnology and Bioengineering report.
"This work describes the adaptation to serum deprivation of two human RV packaging cell lines, 293 FLEX and Te Fly and its effects on lipid biosynthetic pathways and infectious vector production. Total...
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Source: Gene Therapy Weekly (2012-05-10)
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