Osteoporosis
Findings in Osteoporosis Reported from Seoul National University
Published in Gene Therapy Weekly, May 10th, 2012
2012 MAY 10 -- "The imbalance between bone-resorbing osteoclasts and bone-forming osteoblasts often leads to bone destructive diseases such as osteoporosis. In contrast to the development of several antiresorptive agents for osteoporosis therapy, discovery of anabolic drugs has been difficult because of an insufficient understanding of the complex mechanism of bone formation," researchers in Seoul, South Korea report.
"In a microarray analysis with mouse preosteoblast cells, we found that PlexinA2 (PlxnA2), a molecule previously known to mediate axon guidance in neural development, was upregulated by the osteogenic factor BMP2. PlxnA2-specific siRNA...
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Source: Gene Therapy Weekly (2012-05-10)
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