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Lymphoma

Research from University of Cambridge Provide New Insights into Lymphoma

Published in Gene Therapy Weekly, May 17th, 2012

2012 MAY 17 -- A report, "BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas," is newly published data in Haematologica. According to the authors of recent research from Cambridge, United Kingdom, "The genetics and pathogenesis of splenic marginal zone lymphoma are poorly understood. The lymphoma lacks chromosome translocation, and approximately 30% of cases are featured by 7q deletion, but the gene targeted by the deletion is unknown."

"A recent study showed inactivation of A20, a 'global' NF-'B negative regulator, in 1 of 12 splenic marginal zone lymphomas. To investigate further whether...

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